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Molecular Probes for Fluorescence Imaging of ATP in Cells and Tissues
Author(s) -
Jun Yong Woong,
Sarkar Sourav,
Kim Kyeong Hwan,
Ahn Kyo Han
Publication year - 2019
Publication title -
chemphotochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 18
ISSN - 2367-0932
DOI - 10.1002/cptc.201900001
Subject(s) - adenosine triphosphate , biomolecule , fluorescence , biophysics , chemistry , nanotechnology , biochemistry , microbiology and biotechnology , biology , materials science , physics , quantum mechanics
Adenosine triphosphate (ATP), as the main energy source in cells, powers most cellular activities, such as synthesis and transportation of biomolecules, cell signaling, and muscle contraction. Therefore, detection and monitoring of ATP are essential to understand many biological processes, demanding molecular probes with high selectivity and sensitivity, fast response times, along with long‐term monitoring and tissue imaging capability. We overviewed the reported small‐molecule fluorescent probes for ATP by categorizing their recognition elements, along with comments on their merits and limitations. Also, we briefly stated the desirable properties, challenges, and perspectives in the development of ATP probes.