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Rapid Production of trans ‐Cyclooctenes in Continuous Flow
Author(s) -
BlancoAnia Daniel,
Maartense Luuk,
Rutjes Floris P. J. T.
Publication year - 2018
Publication title -
chemphotochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 18
ISSN - 2367-0932
DOI - 10.1002/cptc.201800128
Subject(s) - continuous flow , substrate (aquarium) , materials science , extraction (chemistry) , nitrate , production (economics) , scale (ratio) , nanotechnology , chemical engineering , chemistry , process engineering , chromatography , organic chemistry , biochemical engineering , physics , engineering , quantum mechanics , economics , macroeconomics , geology , oceanography
A new method for rapid larger‐scale production of trans ‐cyclooctenes (TCOs) in continuous flow was developed: Up to 2.2 g/h of specific TCOs can be produced by using this procedure. This method utilizes the classical photoisomerization of cis ‐cyclooctenes (CCOs) for the synthesis of TCOs but substitutes the conventionally used silver nitrate impregnated silica gel column for a liquid−liquid extraction module. In addition, this method provides the possibility of external addition of a substrate to scale up and speed up the production of TCOs because the concentration of the CCO is kept constant. This method was applied for the synthesis of several commonly used TCOs.