Premium
Multi‐Step Continuous Flow Synthesis of β/γ‐Substituted Ketones
Author(s) -
Garbarino Silvia,
Protti Stefano,
Gabrielli Serena,
Fagi Maurizio,
Palmieri Alessandro,
Ravelli Davide
Publication year - 2018
Publication title -
chemphotochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 18
ISSN - 2367-0932
DOI - 10.1002/cptc.201800107
Subject(s) - aldehyde , sulfone , sulfonyl , continuous flow , enone , chemistry , ketone , flow chemistry , organic chemistry , combinatorial chemistry , catalysis , alkyl , physics , mechanics
The smooth preparation of β/γ‐substituted ketones has been carried out by using a three‐step continuous flow synthesis involving the initial photocatalyzed addition of an aldehyde onto phenyl vinyl sulfone. The resulting β‐ketosulfones were then elaborated in flow to prepare in situ an enone upon basic elimination of the sulfonyl group and then to give γ‐nitroketones, a 4‐chromanone, and β‐(3‐indolyl)ketones in moderate to good yields.