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Continuous Flow for the Photochemical C‐H Amination of Arenes
Author(s) -
Cosgrove Sebastian C.,
Douglas Gayle E.,
Raw Steven A.,
Marsden Stephen P.
Publication year - 2018
Publication title -
chemphotochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 18
ISSN - 2367-0932
DOI - 10.1002/cptc.201800105
Subject(s) - amination , continuous flow , chemistry , amine gas treating , radical , photodissociation , photochemistry , flow (mathematics) , batch processing , flow chemistry , combinatorial chemistry , organic chemistry , catalysis , computer science , mathematics , biochemical engineering , geometry , engineering , programming language
The direct C−H amination of arenes by aminium radicals generated by photolysis of N ‐chloroamines is demonstrated under continuous flow conditions. The reactions proceed with comparable efficiency to small scale batch processes but are superior to larger scale batch operations. The continuous generation of the N ‐chloroamine from the amine precursor can be integrated into the process, facilitating the continuous direct conversion of secondary amines to their arylated derivatives.