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Liquid‐Liquid Slug‐Flow‐Accelerated [2+2] Photocycloaddition of Cinnamates
Author(s) -
Telmesani Reem,
White Jada A. H.,
Beeler Aaron B.
Publication year - 2018
Publication title -
chemphotochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 18
ISSN - 2367-0932
DOI - 10.1002/cptc.201800081
Subject(s) - cinnamates , substrate (aquarium) , chemistry , catalysis , slug flow , photochemistry , scope (computer science) , flow (mathematics) , organic chemistry , computer science , mechanics , physics , two phase flow , geology , oceanography , programming language
[2+2] photocycloaddition of cinnamates, using a previously described cone reactor and a bis‐thiourea catalyst, is greatly accelerated by employing liquid–liquid slug flow. In most cases, a four‐fold acceleration in reaction time was observed with equivalent or superior yields. This approach has enabled significant improvement in the reaction throughput and expansion of the substrate scope to include challenging substrates. It has also enabled, to our knowledge, the first reported direct photodimerization in solution of electron‐rich cinnamamide substrates.