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Cover Picture: Saposin B Binds the Lipofuscin Bisretinoid A2E and Prevents its Enzymatic and Photooxidation (ChemPhotoChem 6/2017)
Author(s) -
Tinklepaugh Jay,
Smith Britannia M.,
Nie Yan,
Moody Kelsey,
Grohn Kris,
BouAbdallah Fadi,
Doyle Robert P.
Publication year - 2017
Publication title -
chemphotochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.13
H-Index - 18
ISSN - 2367-0932
DOI - 10.1002/cptc.201700083
Subject(s) - lipofuscin , enzyme , pigment , chemistry , macular degeneration , degeneration (medical) , biochemistry , degradation (telecommunications) , biophysics , biology , computer science , medicine , pathology , organic chemistry , telecommunications , ophthalmology
The Front Cover picture illustrates lipofuscin bisretinoid A2E blue‐light‐induced photooxidation and its protection by the lysosomal protein Saposin B (SapB). Binding of A2E, a common bisretinoid found in granules in patients with age‐related macular degeneration, by SapB protects A2E from both enzymatic degradation and photooxidation by blue light. More information can be found in the Communication by R. P. Doyle and co‐workers on page 256 in Issue 6, 2017 (DOI: 10.1002/cptc.201700039).