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Plasma renin concentration and phenobarbital levels in patients with epilepsy
Author(s) -
Booker Harold E.,
Goodfriend Theodore L.,
Tewksbury Duane A.
Publication year - 1979
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1979266715
Subject(s) - phenobarbital , epilepsy , plasma renin activity , pharmacology , medicine , plasma concentration , renin–angiotensin system , endocrinology , psychiatry , blood pressure
Plasma renin activity, renin concentration, and renin substrate were measured in patients on long‐term anticonvulsant medication. An inverse correlation was observed between phenobarbital levels and renin activity or concentration. There was a positive correlation between phenobarbital and renin substrate. Since elevation of renin substrate should have resulted in increased renin activity, it is possible that phenobarbital exerts 2 effects on the renin system: induction of renin substrate synthesis and suppression of renin release.