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Effect of imipramine on norepinephrine and blood pressure in enuretic boys
Author(s) -
Lake C. R.,
Mikkelsen E. J.,
Rapoport J. L.,
Zavadil A. P.,
Kopin I. J.
Publication year - 1979
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1979265647
Subject(s) - imipramine , blood pressure , bedtime , tricyclic , norepinephrine , placebo , stimulant , desipramine , medicine , drug , endocrinology , anesthesia , pharmacology , alternative medicine , pathology , hippocampus , antidepressant , dopamine
The effect of imipramine, desmethylimipramine, and methscopolamine on blood pressure (BP) and plasma norepinephrine (NE) was measured in enuretic boys in a double‐blind, placebo‐controlled study. Measurements were obtained on the thirteenth day of medication (75 mg at bedtime). The tricyclic drugs induced a rise in diastolic BP as well as an increase in plasma NE but there was no significant relationship between the increments in plasma NE and BP. The plasma concentration of drug correlated with the drug‐induced BP rise. This is the fifth study to demonstrate a hypertensive effect of tricyclic drugs in children in contrast to the systolic hypotension usually seen in adult patients. It is not clear from our data whether children have different cardiovascular compensatory reflexes or whether they experience a greater stimulant effect from the drug.