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N ‐Acetylprocainamide pharmacokinetics in functionally anephric patients before and after perturbation by hemodialysis
Author(s) -
Stec G. Paul,
Atkinson Arthur J.,
Nevin Mary Jane,
Thenot Jean-Paul,
Ruo Tsuen I.,
Gibson Thomas P.,
Ivanovich Peter,
Greco Francesco
Publication year - 1979
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1979265618
Subject(s) - napa , pharmacokinetics , hemodialysis , dialysis , plasma clearance , urology , renal function , pharmacology , chemistry , medicine , endocrinology , biochemistry
NAPA pharmacokinetics were studied in 6 functionally anephric patients. Distribution and nonrenal elimination of this drug were found to be the same as in individuals with normal renal function but renal clearance was reduced, resulting in a mean elimination t½ of 41.9 hr (6.2 hr in normal subjects). Renal clearance of NAPA correlated well with Cl Cr . Dialysis removed NAPA from both red blood cells and plasma and increased ClTapproximately fourfold. Dialysis itself resulted in a 77% reduction in Cl s that limited the total amount of NAPA removed by this procedure. This reduction in Cl s was sustained for at least 3 hr after dialysis and attenuated rebound in plasma NAPA concentrations.