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Sulfinpyrazone kinetics after intravenous and oral administration
Author(s) -
Lecaillon Jean B.,
Souppart Claire,
Schoeller Jean-Paul,
Humbert Guy,
Massias Pierre
Publication year - 1979
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1979265611
Subject(s) - sulfinpyrazone , compartment (ship) , pharmacokinetics , kinetics , plasma concentration , oral administration , pharmacology , chemistry , drug , medicine , aspirin , oceanography , physics , quantum mechanics , geology
Sulfinpyrazone kinetics has been investigated after intravenous and oral doses. They may be described by a 3‐compartment open model. In the body about half the drug is in the plasma or in interstitial fluids, which are readily equilibrated with plasma. Most of the rest is in an extravascular compartment, from which it easily diffuses back to the plasma. About 3% of the dose is still in the body after 24 hr and is located mainly in a deep compartment. After oral administration, sulfinpyrazone is quickly absorbed, largely from the stomach.