Premium
Cefamandole kinetics in uremic patients undergoing hemodialysis
Author(s) -
Gambertoglio John G.,
Aziz Nik S.,
Lin Emil T.,
Grausz Henry,
Naughton James L.,
Benet Leslie Z.
Publication year - 1979
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1979265592
Subject(s) - cefamandole , hemodialysis , medicine , dialysis , urology , urine , urinary system , surgery , chemistry , cephalosporin , biochemistry , antibiotics
A single intravenous 15 mg/kg dose of cefamandole was given to 6 patients in chronic renal failure before hemodialysis, and 3 were examined during an interdialysis period. Mean cefamandole clearance by hemodialysis was 24 ± 12 ml/min; 35 ± 15% of the dose was recovered in the dialysate. The cefamandole half‐life (t½) on dialysis was 4.0 ± 0.29 hr; off dialysis it was 13.9 ±4.2 hr. High urine concentrations of cefamandole in these patients suggests usefulness in urinary tract infections.