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Hemodynamic effects of intravenous timolol in coronary artery disease
Author(s) -
Chew Christopher Y. C.,
Collett John,
Shah Prediman K.,
Singh Bramah N.
Publication year - 1979
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1979263330
Subject(s) - timolol , medicine , vascular resistance , hemodynamics , propranolol , cardiology , coronary artery disease , cardiac index , blood pressure , cardiac catheterization , anesthesia , heart rate , cardiac output , intraocular pressure , surgery
The hemodynamic effects of intravenous timolol were evaluated in 20 patients with coronary artery disease during diagnostic cardiac catheterization. The threshold dose of 0.25 mg reduced heart rate and cardiac index by 15% (p < 0.05), left ventricular work index by 21% (p < 0.05), and left ventricular dp/dt by 16% (p < 0.05) while increasing left ventricular end‐diastolic pressure by 49% (p < 0.01), mean pulmonary arterial pressure by 17% (p < 0.01), and systemic vascular resistance by 16% (NS). Larger doses (0.5 mg and 1.0 mg) induced similar responses with a greater effect on systemic vascular resistance (+22%, p < 0.01, and +31%, p < 0.001). The mean arterial pressure and stroke volumes were not affected by timolol. Peak effects, occurring at about 10 min after drug injection, did not correlate with plasma levels. The overall hemodynamic effects of timolol were similar to those reported for equipotent doses of propranolol and could be accounted for by the β‐adrenoceptor blocking activity.