Premium
The antipyrine test in clinical pharmacology: Conceptions and misconceptions
Author(s) -
Vesell Elliot S.
Publication year - 1979
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1979263275
Subject(s) - clinical pharmacology , test (biology) , pharmacology , medicine , biology , paleontology
Since its introduction 11 years ago, 75, 77 the antipyrine test, devised to determine quantitatively the effect of individual environmental factors on hepatic drug‐metabolizing capacity in normal subjects, has been widely used by clinical pharmacologists, as indicated by the large number of applications listed in Table 1. Yet there have been several technical modifications, new extensions and unresolved problems, and an increasing number of apparently conflicting results. This warrants a fresh look at the antipyrine test and a critical reassessment of its applications and limitations.