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Effect of neuroleptic drugs on lithium uptake by the human erythrocyte
Author(s) -
Pandey Ghanshyam N.,
Goel Indra,
Davis John M.
Publication year - 1979
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197926196
Subject(s) - lithium (medication) , phenothiazine , pharmacology , antidepressant , chemistry , neurotoxicity , in vitro , medicine , toxicity , biochemistry , hippocampus
We studied the effects of neuroleptic and antidepressant drugs on Li + uptake in human red cells to examine the reported neurotoxicity reported for lithium‐neuroleptic combination treatment and its relationship to altered tissue Li + levels. All the phenothiazines increased Li + influx in red cells and steady‐state Li + distribution ratio in vitro. This effect was not observed with other drugs studied. It is suggested that increased levels of Li + in the tissue caused by phenothiazines may be related to neurotoxic effects observed during Li + ‐phenothiazine therapy.