Effect of neuroleptic drugs on lithium uptake by the human erythrocyte | Zendy

Pandey Ghanshyam N. | Zendy; Goel Indra | Zendy; Davis John M. | Zendy

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Effect of neuroleptic drugs on lithium uptake by the human erythrocyte

Author(s) -

Pandey Ghanshyam N.,

Goel Indra,

Davis John M.

Publication year - 1979

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1002/cpt197926196

Subject(s) - lithium (medication) , phenothiazine , pharmacology , antidepressant , chemistry , neurotoxicity , in vitro , medicine , toxicity , biochemistry , hippocampus

We studied the effects of neuroleptic and antidepressant drugs on Li + uptake in human red cells to examine the reported neurotoxicity reported for lithium‐neuroleptic combination treatment and its relationship to altered tissue Li + levels. All the phenothiazines increased Li + influx in red cells and steady‐state Li + distribution ratio in vitro. This effect was not observed with other drugs studied. It is suggested that increased levels of Li + in the tissue caused by phenothiazines may be related to neurotoxic effects observed during Li + ‐phenothiazine therapy.

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