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Lack of effect of bran on digoxin absorption
Author(s) -
Woods Margo N.,
Ingelfinger Joseph A.
Publication year - 1979
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197926121
Subject(s) - digoxin , bran , absorption (acoustics) , confidence interval , chemistry , serum concentration , medicine , endocrinology , pharmacology , materials science , heart failure , raw material , organic chemistry , composite material
The effect of dietary fiber on digoxin absorption was investigated in 12 patients taking digoxin. Steady‐state serum digoxin concentrations were determined while subjects were on a regular diet and while they were on a diet supplemented with 22 gm bran daily. During the period of bran supplementation, the serum digoxin concentration did not change (average change, +0.5%; 90% confidence interval, −12% to +14%). Bran does not cause a clinically significant reduction in digoxin absorption.