Lack of effect of bran on digoxin absorption | Zendy

Woods Margo N. | Zendy; Ingelfinger Joseph A. | Zendy

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Lack of effect of bran on digoxin absorption

Author(s) -

Woods Margo N.,

Ingelfinger Joseph A.

Publication year - 1979

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1002/cpt197926121

Subject(s) - digoxin , bran , absorption (acoustics) , confidence interval , chemistry , serum concentration , medicine , endocrinology , pharmacology , materials science , heart failure , raw material , organic chemistry , composite material

The effect of dietary fiber on digoxin absorption was investigated in 12 patients taking digoxin. Steady‐state serum digoxin concentrations were determined while subjects were on a regular diet and while they were on a diet supplemented with 22 gm bran daily. During the period of bran supplementation, the serum digoxin concentration did not change (average change, +0.5%; 90% confidence interval, −12% to +14%). Bran does not cause a clinically significant reduction in digoxin absorption.

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