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Renal excretion of cephapirin and cephaloridine: Evidence for saturable tubular reabsorption
Author(s) -
Arvidsson Annie,
Borgå Olof,
Alvan Gunnár
Publication year - 1979
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1979256870
Subject(s) - cephaloridine , reabsorption , chemistry , urine , renal physiology , renal function , excretion , diuretic , endocrinology , high performance liquid chromatography , medicine , cephalosporin , pharmacology , kidney , chromatography , antibiotics , biochemistry
Drug concentrations in plasma and urine were determined in 5 healthy subjects after intravenous infusion of 1 gm cephapirin and cephaloridine. Sampling of blood and urine was frequent and prolonged. Specimens were analyzed by high‐pressure liquid chromatography (HPLC). Renal clearance of cephapirin decreased to less than 5% of control in all subjects when drug concentrations in plasma and urine declined. Cephaloridine clearance decreased to a lesser extent. Our findings suggest that, besides tubular secretion and glomerular filtration, a saturable and probably active tubular reabsorption is also involved in the renal handling of these two cephalosporins. The saturable reabsorption process was characterized by its Michaelis‐Menten constant K m and its maximum transport capacity T m .