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Drug‐related transient dyskinesias
Author(s) -
Osifo Nosakhare G.
Publication year - 1979
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1979256767
Subject(s) - chloroquine , transient (computer programming) , medicine , drug , extrapyramidal symptoms , pharmacology , amodiaquine , movement disorders , computer science , psychiatry , antipsychotic , immunology , disease , malaria , schizophrenia (object oriented programming) , operating system
The ability of some antimalarials, especially chloroquine and amodiaquine, to provoke alarming but transient extrapyramidal movement disorders has been reported. The basis of the reported extrapyramidal symptoms has been the cause of some speculation. This paper reviews case reports and presents some data of the regional uptake of chloroquine in mammalian brain as a factor to consider, along with other factors that could influence the action of chloroquine on the extrapyramidal system. A neuropharmacologic mechanism for the transient extrapyramidal disturbances has been formulated.