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Single and divided doses of penbutolol
Author(s) -
Müller F. O.,
Hundt H. K. L.,
Bromley P. A.,
Torres J.,
Vanderbeke O.
Publication year - 1979
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1979255part1528
Subject(s) - medicine , pharmacology , computer science
Penbutolol, a nonselective β‐adrenoceptor antagonist, induced reduction of exercise‐induced heartbeats for at least 24 hr after a single 40‐mg oral dose, and was equipotent with respect to a 2 × 20‐mg regimen over the same period. Ingestion for 7 days did not influence the pharmacodynamics or pharmacokinetics of penbutolol, and there was no cumulation of drug in serum. A relationship was found between the logarithms of measurable serum concentrations of penbutolol and the percentage reduction of total heartbeats. Absorption of oral penbutolol appeared to be reduced when administered in the evening. Since β‐adrenoceptor activity was relatively unchanged between 13 and 24 hr after a single 40‐mg dose of penbutolol, there is a possibility that an active metabolite or metabolites may contribute to prolonged duration of action.