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Site of renal action of xipamide
Author(s) -
Gold Clive H.,
Viljoen Margaretha
Publication year - 1979
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1979255part1522
Subject(s) - hydrochlorothiazide , furosemide , diuretic , chemistry , reabsorption , free water clearance , diuresis , thiazide , kidney , medicine , renal function , blood pressure , biochemistry , organic chemistry
Xipamide, hydrochlorothiazide, andfurosemide were given to normal volunteers on a double‐blind basis. During maximal water diuresis, there was a reduction in free water clearance and an increase in osmolar clearance after administration of xipamide and hydrochlorothiazide, but not in the case of furosemide. During maximal hydropenia, both xipamide and hydrochlorothiazide increased free water reabsorption in a linear relationship to osmolar clearance, while furosemide increased osmolar clearance with little change in free water reabsorption. It was concluded, therefore, that, as with hydrochlorothiazide, the site of action of xipamide was on the distal convoluted tubule, and that of furosemide on the loop of Henle.