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Kinetics of cis ‐dichlorodiammineplatinum
Author(s) -
Gormley Paul E.,
Bull Joan M.,
LeRoy Andre F.,
Cysyk Richard
Publication year - 1979
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1979253351
Subject(s) - clearance , platinum , chemistry , excretory system , urine , renal function , pharmacokinetics , excretion , medicine , endocrinology , pharmacology , chromatography , urology , biochemistry , catalysis
The cancer chemotherapeutic cis‐dichlorodiammineplatinum (cis‐DDP) was administered to 8 patients (1‐hr intravenous infusion) at a dose of 70 mg/m 2 . Plasma and urine concentrations of platinum were determined by flame less atomic absorption spectrometry. Measured plasma platinum concentrations revealed a biphasic clearance of platinum with half‐life values of 23 min and 67 hr. Platinum values obtained 3 wk after the infusion indicated that a third excretory phase might be present. Urinary measurements showed 17 ± 2.7% of the administered dose excreted in the first 4 hr and 23 ± 3.9% excreted in the first 24 hr. Renal excretion appears to be predominantly by glomerular filtration. Non‐protein‐bound plasma platinum values were calculated and the non‐protein‐bound platinum was found to be rapidly and biphasically cleared from the plasma with half‐life values of 8 to 10 min and 40 to 45 min.