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Urinary excretion of D‐glucaric acid by severely burned patients
Author(s) -
Ciaccio Edward I.,
Fruncillo Richard J.
Publication year - 1979
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1979253340
Subject(s) - video graphics array , medicine , excretion , urinary system , endocrinology , chip , electrical engineering , engineering
The 24‐hr excretion of urinary D‐glucaric acid (VGA) has been measured in 5 seriously burned adults and compared with 6 healthy adults. In the burn patients mean VGA was 14.4 ± 5.4 (±SD) µmoles/day and 28.7 ± 6.5 pmoleslday in controls (p < 0.002). In a 6‐year‐old female, VGA was also found to be very low. In a seventh burn patient, an adult male taking 20 mg of fluphenazine until his injury, his VGA was still in the normal range (29 µmoles/day) on the day of admission but descended to 21 µmoles/day at 2 days, to 16 at 4 days, and to 13 at 6 days. Treatment with fiuphenazine was then reinstituted and on the tenth day VGA was 28 µmoles/day, indicating that after thermal injury VGA can respond to drugs. Although the inference has not been proved that decreased VGA corresponds to a decreased activity of drug metabolism, there is evidence of a strong correlation between increased VGA and increased drug metabolism. A decrease of VGA in disorders that generally lower metabolic activity supports a possible correlation in severe burns. If drug metabolism activity is lowered in the seriously burned patient, drug overdose may well result from the usual clinical doses.