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Effect of indomethacin on salt and water homeostasis
Author(s) -
Brater D. Craig
Publication year - 1979
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1979253322
Subject(s) - chemistry , free water clearance , sodium , excretion , endocrinology , medicine , reabsorption , fractional excretion of sodium , renal function , renal sodium reabsorption , renal physiology , homeostasis , potassium , biochemistry , organic chemistry
The effects of indomethacin‐induced prostaglandin inhibition on sodium and chloride homeostasis in normal man were assessed. Seven normal subjects were on a 150‐mEq sodium diet for 3 days prior to receiving indomethacin or no drug. Indomethacin decreased fractional excretions of sodium and chloride without affecting fractional excretion of potassium, creatinine clearance, or percent fractional reabsorption of free water. Cumulative sodium excretion at 8 hr fell from 49.8 ± 7.2 to 16.1 ± 4.8 mEq (p < 0.005) after indomethacin. Chloride fell at 8 hr from 49.7 ± 6.4 to 21.3 ± 5.1 mEq (p < 0.005). Urinary volume and osmolal clearance decreased in similar magnitudes such that free water reabsorption was not changed by indomethacin. This study showed that indomethacin decreased renal sodium and chloride excretion, implying that endogenous prostaglandins may be modulators of renal sodium excretion.