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Effect of food on kinetics of 8‐methoxsalen
Author(s) -
Ehrsson Hans,
Nilsson Sten-Ove,
Ehrnebo Mats,
Wallin Inger,
Wennersten Göran
Publication year - 1979
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1979252167
Subject(s) - methoxsalen , bioavailability , chemistry , absorption (acoustics) , kinetics , elimination rate constant , lag time , reaction rate constant , absorption rate , pharmacokinetics , medicine , pharmacology , zoology , chromatography , biology , materials science , dermatology , volume of distribution , physics , quantum mechanics , biological system , composite material , psoriasis
Kinetics of 8‐methoxsalen were studied in 5 healthy subjects under fasting and nonfasting conditions. The plasma concentration‐time data could be fitted to a zero order absorption one‐compartment model. The area under the curve (AUC) values were higher (p < 0.05) under nonfasting compared to fasting conditions, indicating higher relative bioavailability of the drug in the presence of food. No significant differences were observed in the lag‐time for the start of the absorption, the apparent zero‐order absorption rate constant, or the elimination rate constant. It is suggested that the drug should be taken in a standardized way in relation to food during the ultraviolet (UV) light treatment.