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Bromocriptine inhibits norepinephrine release
Author(s) -
Ziegler M. G.,
Lake C. R.,
Williams A. C.,
Teychenne P. F.,
Shoulson I.,
Steinsland O.
Publication year - 1979
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1979252137
Subject(s) - bromocriptine , norepinephrine , agonist , endocrinology , medicine , dopamine , cerebrospinal fluid , dopamine agonist , dopamine receptor , peripheral , blood pressure , sympathetic nervous system , chemistry , receptor , anesthesia , prolactin , hormone
Bromocriptine is a dopamine agonist that induces postural hypotension and can be used as an antihypertensive. The drug inhibits release of norepinephrine (NE) from an isolated artery by stimulating presynaptic receptors. In normotensive subjects it lowers both plasma and cerebrospinal fluid (CSF) levels of NE by 50% and lowers blood pressure moderately in standing subjects and slightly in recumbent subjects. Through central and peripheral mechanisms, bromocriptine inhibits sympathetic nervous discharge of NE.