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Effect of naproxen on the steady‐state serum concentration and anticoagulant activity of warfarin
Author(s) -
Jain Adesh,
McMahon F. Gilbert,
Slattery John T.,
Levy Gerhard
Publication year - 1979
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197925161
Subject(s) - naproxen , warfarin , anticoagulant , serum concentration , medicine , pharmacology , chemistry , atrial fibrillation , alternative medicine , pathology
The purpose of this investigation was to determine whether the anti‐inflammatory drug naproxen interacts with warfarin during prolonged administration of both drugs. Healthy adults received oral doses of warfarin daily for 26 days. Naproxen, 375 mg twice daily, was given from the eleventh through the twentieth days. Naproxen administration had no apparent effect on the steady‐state concentrations of free and total (free and protein‐bound) warfarin in serum, despite a small but statistically significant increase of the warfarin‐free fraction in serum. There was no apparent difference between the prothrombin times (at a constant daily dose of warfarin) observed before, during, and after administration of naproxen.