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Diurnal rhythms of aminopyrine metabolism: Failure of sleep deprivation to affect them
Author(s) -
Poley Gerald E.,
Shively Carol A.,
Vesell Elliot S.
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978246726
Subject(s) - circadian rhythm , medicine , endocrinology , diurnal temperature variation , chemistry , metabolism , metabolic clearance rate , pharmacokinetics , atmospheric sciences , geology
After a single oral dose of aminopyrine (9 mg/kg), mean salivary aminopyrine half‐lives (t½s) and metabolic clearance rates in 12 normal male volunteers exhibited diurnal variations. Salivary aminopyrine t½s were approximately 50% longer at 8 p.m. (2.1 ± 0.7 hr) than at 8 a.m. (1.4 ± 0.3 hr). Mean aminopyrine metabolic clearance rates decreased 20% from 8 a.m. (418.2 ± 152.0 ml/min) to 8 p.m. (335.3 ± 107.6 ml/min). There were large interindividual variations in the magnitude of these diurnal changes in aminopyrine t½ and metabolic clearance rates. There were nonsignificant changes in mean aminopyrine apparent volumes of distribution (aVd) which increased only slightly from 53.1 ± 20.6 L at 8 a.m. to 59.7 ± 26.5 L at 8 p.m. There were diurnal variations in plasma 11‐hydroxycorticosteroids (11‐0HCS), mean values of which decreased 60% from 16.2 ± 4.2 µg/100 ml at 8 a.m. to 6.5 ± 1.9 µg/100 ml at 8 p.m. Sleeplessness for 24 or 48 hr under the conditions of this experiment failed to affect diurnal rhythms in aminopyrine metabolism or plasma 11‐OHCS concentrations.