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Physostigmine for cardiac and neurologic manifestations of phenothiazine poisoning
Author(s) -
Weisdorf Daniel,
Kramer Jeffrey,
Goldbarg Alberto,
Klawans Harold L.
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978246663
Subject(s) - physostigmine , anticholinergic , tricyclic , medicine , amitriptyline , anticholinergic agents , trifluoperazine , anesthesia , phenothiazine , perphenazine , thioridazine , pharmacology , atropine , cholinesterase , acetylcholine , chlorpromazine , calmodulin , calcium
Psychotropic drugs such as the phenothiazine neuroleptics and tricyclic antidepressants are known to cause electrocardiographic abnormalities as well as a central anticholinergic syndrome. Physostigmine is known to reverse the central muscarinic anticholinergic manifestations by inhibition of the enzyme cholinesterase. An unusual case of trifluoperazine overdose, in which the patient presented with cardiac arrhythmias and a central anticholinergic syndrome, is presented. Treatment with physostigmine reversed the central anticholinergic syndrome as well as the electrocardiographic abnormalities. Effects of phenothiazines on altering cardiac status are also discussed.