Premium
Potential anticoagulant drug interactions in ambulatory patients
Author(s) -
Hull J. Heyward,
Murray William J.,
Brown H. Shelton,
Williams Benjamin O.,
Chi Shelly L.,
Koch Gary G.
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978246644
Subject(s) - ambulatory , drug , medicine , warfarin , concomitant , drug interaction , anticoagulant , pharmacy , medical prescription , drug drug interaction , oral anticoagulant , anticoagulant drug , pharmacology , emergency medicine , atrial fibrillation , family medicine
Computer‐generated prescription drug purchase records for ambulatory patients receiving oral anticoagulants (OAC) were studied for concomitant use of other drugs which have been reported to induce clinically significant interactions. One third of 479 patients taking OAC were exposed to a potentially interacting drug at some time during this 6‐month period. The percentage of patients with drug interaction exposure correlated directly with total drug use (p < 0.0005). There were no significant differences when interaction exposure rates were compared in the cases of single: multiple pharmacy and single: multiple physician‐patient groups. Warfarin was the most common anticoagulant (>95%) and barbiturates the most common interacting drug.