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Interaction of disulfiram with benzodiazepines
Author(s) -
MacLeod S. M.,
Sellers E. M.,
Giles H. G.,
Billings B. J.,
Martin P. R.,
Greenblatt D. J.,
Marshman J. A.
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978245583
Subject(s) - oxazepam , disulfiram , chlordiazepoxide , diazepam , benzodiazepine , pharmacology , disposition , active metabolite , drug interaction , pharmacokinetics , medicine , chemistry , psychology , social psychology , receptor
The disposition of chlordiazepoxide (50 mg, intravenously), diazepam (0.143 mg/kg, orally), and oxazepam (0.429 mg/kg, orally) were studied in normal and alcoholic men before and after chronic disulfiram administration. Decreases in the plasma clearance of chlordiazepoxide (54%, p < 0.05), diazepam (41%, p < 0.05), and their active N‐desmethyl metabolites were observed. Oxazepam has no important active metabolites and its net disposition is minimally altered by disulfiram. Oxazepam disposition is unaffected by age and liver disease. These considerations together with that of the short half‐life of oxazepam (median, 6.1 hr) suggest that oxazepam may be the drug of choice if benzodiazepine therapy is used for patients taking disulfiram.