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Placental transfer of furosemide
Author(s) -
Beermann Björn,
Groschinsky-Grind Margaretha,
Fåhraeus Lars,
Lindström Björn
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978245560
Subject(s) - furosemide , umbilical vein , medicine , umbilical cord , amniotic fluid , pregnancy , fetus , drug administration , vein , endocrinology , chemistry , biology , anatomy , biochemistry , genetics , in vitro
After oral administration of furosemide to 18 pregnant women on the day of delivery, substantial concentrations of the drug were detected in umbilical cord vein plasma as well as in amniotic fluid. The ratio between the furosemide concentrations in maternal vein plasma and in umbilical cord plasma increased with time and approximated unity at 8 to 10 hr after administration of the drug. The plasma half‐life offurosemide appeared to be longer in the mothers than in nonpregnant healthy volunteers. In one patient the plasma level of furosemide was constant during 5 hr of observation.