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Enhanced biotransformation of theophylline in marihuana and tobacco smokers
Author(s) -
Jusko William J.,
Schentag Jerome J.,
Clark John H.,
Gardner Mark,
Yurchak Anthony M.
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978244406
Subject(s) - theophylline , clearance , medicine , pharmacology , cannabis , nicotine , marijuana smoking , physiology , polysubstance dependence , substance use , urology , clinical psychology , psychiatry
Single oral doses of theophylline were administered to 7 chronic marihuana smokers, to 7 chronic users of both marihuana and tobacco, and to 43 appropriate control subjects. Theophylline was cleared from the blood more rapidly in both marihuana and tobacco smokers with a mean increase in total clearance from 52 ml/kg/hr in nonsmokers to 74 ml/kg/hr in subjects who smoked either material alone. There was an additive increase in clearance to 93 m/lkg/hr in those who smoked both substances. Concern over enhanced metabolism of other drugs is probably warranted in tobacco and cannabis smokers.