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Combined effects of fenmetozole and ethanol
Author(s) -
Griffis Larry C.,
Bright Thomas P.,
Cerimele Benito J.,
Forney Robert B.
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978243350
Subject(s) - ethanol , ingestion , medicine , psychology , anesthesia , chemistry , biochemistry
Eight male subjects took none or 200 mg fenmetozole 1 hr before drinking a beverage containing none or 50 m/l70 kg ethanol. Tests designed to measure mental and motor performance were administered 2 hr after fenmetozole ingestion. Fenmetozole alone impaired standing steadiness but improved mental performance in one test. Fenmetozole did not antagonize the decrement in performance induced by this amount of ethanol. In combination, the subjective symptoms caused by fenmetozole were additive with those of ethanol.