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Effeets of folie aeid on phenytoin kineties in healthy subjeets
Author(s) -
Furlanut M.,
Benetello P.,
Avogaro A.,
Dainese R.
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978243294
Subject(s) - phenytoin , urine , disposition , folic acid , medicine , endocrinology , excretion , free fraction , pharmacology , chemistry , epilepsy , pharmacokinetics , psychology , social psychology , psychiatry
Phenytoin (DPH) disposition was studied in normal subjects before and after treatment with folic acid for 14 days. Our results suggest that folic acid lowers DPH serum levels without significantly modifying its bound fraction and inereases the rate of DPH and meta‐hydroxydiphenylhydantoin excretion in urine.