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Assessing the subjective effects of stimulants in casual users; A methodology and preliminary results
Author(s) -
Cole Jonathan O.,
Pope Harrison G.,
LaBrie Richard,
Ionescu-Pioggia Martin
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978242243
Subject(s) - casual , medicine , psychology , pharmacology , political science , law
In order to assess the subjective effects of nefopam, a new non‐opiate analgesic, a study was designed using highly educated, young, middle‐to‐upper dass subjects in a naturalistic setting. Results suggest that the design is capable of differentiating variations in subjective drug effects. On a number of measures, 10 mg of d‐amphetamine, a modest dosage, could be distinguished from placebo, showing changes in the direction expected for stimulant drugs. Nefopam (90 mg), on the other hand, showed few differences from placebo or caffeine (300 mg). Nefopam appeared mildly dysphoric, rather than stimulant, in subjective effects.