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Minocycline and doxycycline kinetics in chronic renal failure
Author(s) -
Heaney David,
Eknoyan Garabed
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978242233
Subject(s) - doxycycline , medicine , minocycline , urine , chronic renal failure , urology , urinary system , gastroenterology , pharmacology , surgery , antibiotics , chemistry , biochemistry
Half‐lives and urinary excretion rates of minocycline (MINO) and doxycycline (DOXY) were compared in 8 normal volunteers and in 8 patients with chronic renal failure. Each drug was given as a single, 200‐mg intravenous infusion with a 7‐day period between doses. Blood sampies for serum levels were taken just prior to and at the completion of infusion (0 hr) and then I, 2, 4, 8, 12, 24, 36, 48, 60, and 72 hr later. Urine sampies were collected every 6 hr on day 1, every 12 hr on day 2, and every 24 hr on day 3. Peak serum levels occurred at 0 hr immediately upon completion of the infusion with both drugs. Mean serum levels for MINO were consistently lower than those for DOXY in both groups. Mean serum half‐lives (t ½ ) increased from 14.6 hr (MINO) and 13.8 hr (DOXY) in normal subjects to 17.3 hr (MINO) and 20.6 hr (DOXY) in renal failure patients. Although there was not a statistically significant difference between the mean areas under the serum level curves (AUC) of the normal and the renal failure groups for either drug, the AUC was identical for both groups receiving minocycline and 37% higher than normal for the renal failure group receiving doxycycline. At 72 hr, the normal group had excreted 11% (MINO) and 57% (DOXY) of the dose whereas the renal failure group excreted 0.7% (MINO) and 2.0% (DOXY). These differences between normal and renal failure groups were significant (p < 0.01). Overall, excretion of minocycline was virtually independent of renal function, whereas doxycycline appeared to accumulate to some degree in the renal failure patients.