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Effect of human growth hormone on amobarbital metabolism in children
Author(s) -
Redmond Geoffrey P.,
Bell Jennifer J.,
Perel James M.
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978242213
Subject(s) - amobarbital , metabolism , endocrinology , medicine , drug metabolism , human growth hormone , hormone , microsome , growth hormone , chemistry , biochemistry , in vitro , psychiatry , epilepsy
Drug metabolism changes during the course of growth and development. Hormones mediate somatic growth and may mediate other developmental changes. To determine the effect of human growth hormone (hGH) on human drug metabolism, 6 hGH‐deficient children were given single oral doses of amobarbital before and 6 wk after beginning hGH replacement therapy. Amobarbital was selected as a marker of hepatic microsomal oxidation. Half‐lives rose from 13.89 ± 2.78 hr to 22.75 ± 3.97 hr, volume of distribution was unchanged, and clearance fell from 62.2 ± 15.2 ml/kg/hr to 31.2 ± 11.4 ml/kg/hr. Results indicate that hGH slows the metabolism of amobarbital, probably through an effect on the hepatic microsomal drug‐oxidizing system.