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Influence of corticosteroid on hexobarbital and tolbutamide disposition
Author(s) -
Breimer D. D.,
Zilly W.,
Richter E.
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978242208
Subject(s) - tolbutamide , hexobarbital , prednisone , pharmacokinetics , disposition , pharmacology , medicine , corticosteroid , endocrinology , chemistry , psychology , diabetes mellitus , in vitro , microsome , biochemistry , social psychology
The influence of 10 days' prednisone treatment on the disposition of hexobarbital and tolbutamide was studied in 7 healthy male volunteers. No significant changes in the pharmacokinetic parameters of the two drugs became apparent, which indicates that prednisone pretreatment does not affect their metabolic activities.