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Pamatolol: Phase I evaluation of the pharmacodynamics of a cardioselective beta adrenoceptor blocking drug
Author(s) -
Carruthers S. George,
Hosler James P.,
Pentikainen Pertti,
Azarnoff Daniel L.
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978242168
Subject(s) - heart rate , pharmacodynamics , medicine , beta adrenoceptor , beta (programming language) , pharmacology , drug , pharmacokinetics , cardiology , adrenergic receptor , anesthesia , blood pressure , receptor , computer science , programming language
A Phase I evaluation of a new beta adrenoceptor blocker, pamatolol, was performed in 10 healthy male volunteers, Minor reductions in standing and exercise and isoproterenol‐induced increases in heart rate were observed with the 10‐mg oral dose and appeared maximal with the 400–600 mg dose. The rate of decline of effect averaged 1.5% of the exercise heart rate/hr. Neither resting systolic time intervals nor post‐exercise pulmonary function was affected by this dose range of pamatolol. Based on the latter responses and the isoproterenol dose response curve, we tentatively conclude that pamatolol is relatively cardioselective in man.