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Effect of cimetidine on renal function in normal man
Author(s) -
Dubb Jeffrey W.,
Stote Robert M.,
Familiar Robert G.,
Lee Kenward,
Alexander Fred
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197824176
Subject(s) - cimetidine , renal function , inulin , bicarbonate , endocrinology , medicine , creatinine , renal physiology , chemistry , reabsorption , excretion , histamine , kidney , biochemistry
To evaluate the effect of acute histamine H 2 ‐receptor blockade on renal function, renal function studies were performed in a control state and after cimetidine. Studies included acid excretion in response to acid loading, bicarbonate reabsorption during bicarbonate infusion, and urinary concentrating ability. Cimetidine produced no significant effect on any of these functions. During bicarbonate infusion, inulin clearance remained constant while creatinine clearance fell, possibly because of an effect on tubular creatinine secretion.