Premium
Aspirin and aspirin‐caffeine in postpartum pain relief
Author(s) -
Jain Adesh K.,
McMahon F. Gilbert,
Ryan Jerome R.,
Unger Deanne,
Richard Wilma
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197824169
Subject(s) - aspirin , analgesic , episiotomy , caffeine , medicine , placebo , anesthesia , acetaminophen , randomized controlled trial , pregnancy , alternative medicine , pathology , biology , genetics
In two double‐blind, randomized, balanced, single oral dose studies with 140 women, a combination of 800 mg aspirin and 64 mg caffeine (aspirin‐caffeine) was compared to 650 mg aspirin and to placebo. In patients with moderate to severe uterine or episiotomy pain, there was greater analgesic response with active drugs when the initial pain intensity was more severe. In patients with severe episiotomy pain, aspirin‐caffeine was more effective than 650 mg aspirin (p < 0.05) at the second and third hours. There was no difference between analgesic effects of aspirin and aspirin‐caffeine in women with severe uterine pain.