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Effect of smoking on caffeine clearance
Author(s) -
Parsons William D.,
Neims Allen H.
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197824140
Subject(s) - caffeine , saliva , volume of distribution , metabolic clearance rate , medicine , chemistry , endocrinology , physiology , pharmacokinetics
The elimination of caffeine from saliva was compared in groups of healthy smokers (n = 13) and nonsmokers (n = 13). Mean caffeine t ½ in smokers (3.5 hr) was shorter than that in the nonsmokers (6.0 hr). The body clearance of caffeine in the smokers (155 ± 16 ml · kg −1 · hr −1 ) was greater than that in the nonsmokers (94 ± 18 ml · kg −1 · hr −1 ) (p < 0.05). No significant difference was noted in the apparent volume of distribution in smokers (720 ± 67 ml . kg‐I) and nonsmokers (610 ± 80 ml · kg −1 ). These differences probably reflect the induction of hepatic aryl hydrocarbon hydroxylase (AHH) activity in smokers. The increased clearance of caffeine by smokers may contribute to the higher consumption of coffee reported to occur in this group.