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Kinetics of mezlocillin and carbenicillin
Author(s) -
Pancoast Stephen J.,
Neu Harold C.
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978241108
Subject(s) - carbenicillin , mezlocillin , kinetics , chemistry , medicine , biology , biochemistry , antibiotics , ampicillin , pseudomonas aeruginosa , physics , genetics , bacteria , piperacillin , quantum mechanics
The kinetics of mezlocillin, a semisynthetic acylureido penicillin, more active than carbenicillin against many gram‐negative bacteria, were compared with those of carbenicillin. Following an intravenous infusion of 4 gm in 5 min to 8 normal men there was an average serum level of 294 µg/ml for mezlocillin and 365 µg/ml for carbenicillin. The t ½ for mezlocillin was 47 min and that for carbenicillin was 70 min. The apparent volume of distribution was 13.4 L for mezlocillin and 14.4 Lfor carbenicillin. The mean urinary recovery of mezlocillin was 72% and that for carbenicillin was 92 %. Constant infusion of 5 mg of mezlocillin over 2 hr gave steady‐state levels of 234 µg/ml. Half‐life, apparent volume of distribution, and serum and renal clearance of mezlocillin after constant infusion were in the same range as those after rapid infusion.