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Effect of glucocorticoids and ACTH on antipyrine clearance in children
Author(s) -
Saenger Paul,
Rifkind Arleen B.,
Pareira Judy
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978236692
Subject(s) - dexamethasone , endocrinology , medicine , adrenocorticotropic hormone , volume of distribution , glucocorticoid , endogeny , stimulation , hydrocortisone , hormone , distribution (mathematics) , metabolism , drug , clearance rate , metabolic clearance rate , drug metabolism , pharmacokinetics , pharmacology , mathematical analysis , mathematics
Administration of dexamethasone and infusion of adrenocorticotropic hormone (ACTH) to children for periods up to 4 days did not alter the half‐life, apparent volume of distribution, or metabolic clearance rate of antipyrine, a drug principally metabolized by the mixed‐function oxidase system of the liver. We conclude that the short‐term administration of glucocorticoids and ACTH with ensuing stimulation of endogenous glucocorticoid production is unlikely to produce clinically significant changes in the rate of drug metabolism.