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Para‐aminosalicylic acid as a lipid‐lowering agent
Author(s) -
Vessby B.,
Lithell H.,
Boberg J.,
Hellsing K.
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978236651
Subject(s) - para aminosalicylic acid , aminosalicylic acid , chemistry , pharmacology , medicine , biochemistry , antibiotics , streptomycin
The capacity of para‐aminosalicylic acid (PAS) to lower initially high serum lipoprotein lipid concentrations was tested in a double‐blind crossover study. Thirty patients who were on a lipid‐lowering diet were treated with PAS (6 gm daily) for 4 wk. There was an average reduction of the serum triglyceride concentration of 28% (p < 0.001) and of 12% of the serum cholesterol concentration (p < 0.001) corresponding to a reduction of very low density lipoprotein (VLDL) triglycerides of 40% (p < 0.001) and low density lipoprotein (LDL) cholesterol of 6% (p < 0.05). In hypercholesterolemic patients, the WL cholesterol reduction was 14% (p < 0.001). In patients with hypertriglyceridemia type IV, the mean reduction of the VWL triglyceride concentration was 47% (p < 0.01), corresponding to a serum triglyceride reduction by 37% (p < 0.01). In spite of the decrease of VWL concentration, there was an unexpected reduction of the lipoprotein lipase activity in adipose tissue of 16% (p < 0.02). The glucose tolerance and the serum insulin concentrations at fasting and after glucose injection were not changed.