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Protriptyline kinetics
Author(s) -
Ziegler Vincent E.,
Biggs John T.,
Wylie Laurence T.,
Coryell William H.,
Hanifl Kathleen M.,
Hawf Donald J.,
Rosen Samuel H.
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978235580
Subject(s) - doxepin , medicine , chemistry , pharmacology , anesthesia
The kinetics of protriptyline were examined in 8 subjects after a single oral dose of 30 mg protriptyline hydrochloride. Peak protriptyline levels ranged from 10.4 to 22.3 ng/ml and were reached 6 to 12 hr after the oral dose. The mean protriptyline half‐life (t ½ ) was 74.3 hr and ranged from 53.6 to 91.7 hr in individual subjects, confirming the long t ½ of protriptyline reported by Moody and associates. The estimated first‐pass metabolism of protriptyline was relatively small, ranging from 10% to 25% of the oral dose, assuming complete absorption. The mean volume of distribution was 22.5 L/kg and ranged from 15.0 to 31.2 L/kg. No relationship was found between the kinetics of protriptyline and those of doxepin studied previously in 7 of the 8 subjects.