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Suppression of renal excretion of digoxin in hypokalemic patients
Author(s) -
Steiness Eva
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978235511
Subject(s) - digoxin , renal function , inulin , hypokalemia , endocrinology , medicine , filtration fraction , excretion , renal physiology , plasma clearance , secretion , aminohippuric acid , potassium , chemistry , pharmacokinetics , renal blood flow , heart failure , biochemistry , organic chemistry
Inulin and digoxin clearances were simultaneously measured in 19 normokalemic and 4 hypokalemic patients. In normokalemia the renal digoxin clearance exceeded the inulin clearance, indicating both glomerular filtration and active tubular secretion of digoxin. The tubular secretion increased with increasing plasma digoxin concentration. In hypokalemia, however, the tubular secretion of digoxin was significantly reduced but increased after the plasma potassium level was raised to normal.