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Cefamandole kinetics during cardiopulmonary bypass
Author(s) -
Polk Ron E.,
Archer Gordon L.,
Lower Richard
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978234473
Subject(s) - cefamandole , cardiopulmonary bypass , medicine , anesthesia , cardiac surgery , surgery , chemistry , cephalosporin , biochemistry , antibiotics
The kinetics of cefamandole during cardiac surgery was studied in 16 adult patients given a single intravenous infusion of 20 mg/kg at the time of anesthesia induction. Five normal volunteers who received the same dose served as controls. Cardiopulmonary bypass (CPB) was found to significantly increase the half‐life (t ½ ) of cefamandole. The mean t ½ during CP B (113.2 min) was longer than the terminal t ½ in normal volunteers (52.0 min; p < 0.005). Throughout CPB (maximum, 3.7 hr), cefamandole plasma levels were maintained above the minimum inhibitory concentration for those organisms most likely to cause postoperative infections. We conclude that if 20 mg/kg of cefamandole is given within an hour of the beginning of cardiovascular surgery, a supplemental dose is not needed until the patient has been on CPB for at least four hours.