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Tetracycline absorption in elderly patients with achlorhydria
Author(s) -
Kramer Paul A.,
Chapron Dennis J.,
Benson Jay,
Mercik Susan A.
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978234467
Subject(s) - achlorhydria , tetracycline , absorption (acoustics) , medicine , microbiology and biotechnology , biology , antibiotics , optics , physics , stomach
Five elderly achlorhydric patients and five controls took 250 mg tetracycline as a capsule or as an oral solution. Venous blood samples drawn during the 12‐hr period following administration and urine collected for 72 hr post‐dosing were assayed fluorometrically for tetracycline. There were no differences between the two groups in either rate or extent of tetracycline absorption. The mean apparent first‐order rate constant (k a ) for absorption of drug from capsules was 0.58 ± 0.17 hr −1 for patients and 0.65 ± 0.21 hr −1 for controls. The mean extent of absorption for capsule dosage forms relative to an oral solution was 1.0 ± 0.20 for patients and 1.0 ± 0.24 for controls. Concurrent administration of 2 gm of sodium bicarbonate to 2 of the normal subjects resulted in no impairment of either the rate or extent of tetracycline absorption from capsules, suggesting that the effect of elevated gastric pH on tetracycline bioavailability may relate to formulation.