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Theophylline disposition in obesity
Author(s) -
Gal Peter,
Jusko William J.,
Yurchak Anthony M.,
Franklin Barry A.
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978234438
Subject(s) - theophylline , aminophylline , volume of distribution , obesity , body water , body weight , medicine , saliva , dosing , disposition , chemistry , pharmacokinetics , endocrinology , psychology , social psychology
Theophylline disposition was examined in 14 obese subjects and 57 normal subjects. A single oral dose of aminophylline solution was given and serum and saliva samples were collected over several hours and assayed by high‐pressure liquid chromatography. The apparent volume of distribution (V d ) and body clearance (Cl B ) were analyzed for total body weight (TBW) and ideal body weight (IBW). The V d averaged 0.482 (SD = 0.084) L/kg TBW in normals vs 0.382 (0.069) L/kg TBW and 0.77 (0.189) L/kg IBW in obese subjects. The Cl B averaged 63.0 (28.5) ml/hr/kg IBW in normals compared to 32.8 (11.1) ml/hr/kg TBW and 64.1 (20.8) ml/hr/kg IBW in obese subjects. Similar V d values between the two groups when TBW is used indicates that loading dose is best calculated based on TBW. Similar Cl B based on lBW in normal and obese subjects indicates that lBW should be used to calculate maintenance doses for theophylline. Mean half‐lives were longer in obese subjects than in normals, 8.6 (2.0) and 6.0 (2.1) hr, respectively, suggesting that obese patients may need less frequent dosing.