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Gastrointestinal microbleeding after aspirin and naproxen
Author(s) -
Lussier André,
Arsenault André,
Varady John
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978234402
Subject(s) - naproxen , aspirin , medicine , crossover study , rheumatoid arthritis , gastroenterology , pharmacology , pathology , alternative medicine , placebo
Gastrointestinal bleeding is the most serious side effect encountered with the anti‐inflammatory antirheumatic drugs. Using the 51 Cr labeling technique, the comparative quantity of blood loss with aspirin or naproxen has been previously done on normal volunteers. With the present study, 12 rheumatoid arthritic patients were controlled in a double‐blind crossover study with the same radioactive technique. There is a difference in favor of naproxen. The difference between the baseline period and naproxen administration was not statistically significant.